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Hi! I’m Ananya Nidamangala Srinivasa, a graduate student in the Zanders Lab, based in Kansas City, MO. I currently work on trying to understand how the wtf meiotic drivers work in Schizosaccharomyces pombe. Meiosis is a specialized form of cell division that some diploid organisms use to make haploid gametes. In a heterozygous organism, post meiosis, each allele is assumed to be equally represented in the gamete population. This Mendelian allele transmission is a fundamental law of genetics. Meiotic drivers break this law by biasing their own transmission into the next generation. They actively or indirectly ensure a higher representation in the progeny. What I love about meiotic drive is the intra-genomic conflict, and the consequences this conflict has over evolutionary time scales.

Mendelian allele transmission assumes that post meiosis, each allele is represented equally (50%). However, a meiotic driver can challenge this by sabotaging the gametogenesis of the gametes that don’t carry the driver allele through diverse mechanisms.

The wtf meiotic drivers in S. pombe are additionally super interesting because of how they drive. I’m currently trying to understand how the wtf drivers destroy spores (yeast gametes) that don’t carry the wtf allele using an approach that combines genetics, molecular biology and microscopy. Find my latest curriculum vitae here.

Beyond studying the wtfs, I want to make science more approachable through art and science communication. To this end, I’m trying to learn, improve, and effectively communicate popular science through my science blog and art. (Hopefully more to come here soon!)

For pleasure, I write and draw beyond science too! I am also a student of Indian classical dance, under the tutelage of Shri A. Lakshmanaswamy in Chennai, India. I draw inspiration from each of these interests to keep learning and discovering new ways to approach science and art.

Publications/ In Press:

Srinivasa, A. N., & Zanders, S. E. (2020). Meiotic drive. Current Biology, 30(11), R627–R629. https://doi.org/10.1016/j.cub.2020.04.023